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KMID : 0903520050480030258
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Journal of the Korean Society of Agricultural Chemistry and Biotechnology
2005 Volume.48 No. 3 p.258 ~ p.262
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Antimicrobial Effects and Antioxidative Activity of Baek-bu-ja (Aconiti koreani Rhizoma) by Extraction Solvent Ratio
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Yoon So-Jung
Kim Jeung-Hoan
Lee Kyoung-Hwan
Kwon Hyo-Jung
Chun Sung-Sook
Cho Young-Je
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Abstract
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For the purpose of developing natural antioxidant, the antioxidative activity and antimicrobial of phenolics isolated from Baek-bu-ja (Aconiti koreani Rhizoma) were determined. Optimum extracting condition for phenolics were water extracts. HPLC analysis showed that the four major phenolic metabolites were rosemarinic, protocatechuic, caffeic and chlorogenic acids. The water extracts of Baekbuja did not have antimicrobial activity against H. pylori; however, the ethanol extracts revealed higher antimicrobial activity. Electron donation ability on DPPH of Baekbuja ethanol extract was 20% higher than other ethanol extracts. The 2,2’-azinobis-3-ethylbenzothiazoline- 6-sulfonic acid radical decolorization (ABTS) and antioxidant protection factor (PF) were determined with extracts from Aconiti koreani Rhizoma. 94% inhibition and 1.14 PF were shown on ABTS and antioxidant protection factor with 60% ethanol extracts. Also, TBARS (thiobarbituric acid reactive substances) showed 0.19 μM in the control and 0.07 μM in the 80% ethanol extracts. The result suggests that Baekbuja extract may be useful as potential sources of anti Helicobacter pylori, antioxidant.
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KEYWORD
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Baekbuja, Aconiti koreani Rhizoma, Helicobacter pylori, antioxidant
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